hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure.
After severe myocardial infarction (MI), heart failure results from ischemia, fibrosis, and remodeling.A promising therapy to enhance cardiac function and induce therapeutic angiogenesis via a paracrine mechanism in MI is myoblast sheet transplantation.We hypothesized that in a giantmouse jagt rat model of MI-induced chronic heart failure, this the